Notify your doctor When you are pregnant or think you might be pregnant. For the duration of pregnancy, this merchandise isn't encouraged. It could damage an unborn newborn. Talk to your health care provider concerning the challenges and great things about this medication. See also Warning part.
The drug is excreted primarily during the urine, largely as inactive metabolites and little quantities of totally free and conjugated morphine. Negligible amounts of codeine and its metabolites are found in the feces.
Promethazine hydrochloride happens being a white to faint yellow, almost odorless, crystalline powder which bit by bit oxidizes and turns blue on prolonged publicity to air.
Codeine is known to be subject matter to abuse; however, the abuse prospective of oral codeine appears to be really reduced. Even parenteral codeine isn't going to surface to supply the psychic outcomes sought by addicts to precisely the same diploma as heroin or morphine.
Given that recurrences of NMS have been documented with phenothiazines, the reintroduction of promethazine HCl should be carefully viewed as.
Speak with your care crew about naloxone and the way to get it. Naloxone can be an emergency medication utilized for an opioid overdose. An overdose can transpire if you are taking a lot of opioid. It may occur if an opioid is taken with Another prescription drugs or substances, like Alcoholic beverages.
Neuroleptic malignant syndrome (NMS) which can cause Loss of life. Show you healthcare service provider instantly When you have any of the subsequent symptoms of NMS:
Though antihistamines happen to be observed to supply fetal mortality in rodents, the pharmacological consequences of histamine from the rodent do not parallel These in man. There aren't any ample and nicely-managed scientific studies of promethazine in Expecting Gals.
Promethazine HCl and Codeine Phosphate Oral Solution really should be made use of with caution in people with bone- marrow despair. Leukopenia and agranulocytosis are actually reported, normally when promethazine is used in Affiliation with other regarded marrow-harmful agents.
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Choose this medication by mouth with or without foodstuff as directed by your health care provider, typically every single 4 to 6 hours as necessary. This medication is often taken with meals if abdomen upset happens. Consume an abundance of fluids whenever you use this medication Until usually directed by your medical doctor.
Postmarketing circumstances of respiratory depression, like fatalities are actually documented with utilization of promethazine in pediatric sufferers.
This is simply not a complete list of achievable Unwanted side effects. In the event you detect other side effects not mentioned previously mentioned, Make contact with your medical doctor or pharmacist.
If this SPL consists of inactivated NDCs outlined via the FDA initiated compliance motion, They are going to be specified as such.